We speak biology.
Fulcrum gives wet-lab scientists a whole department of computational biologists who understand the science and the urgency behind it.
We understand the bases, not just the bytes.
Nice to meet you.
We are bioinformaticians, computational biologists, and software engineers with experience across basic research, technology development, diagnostics, and therapeutics.
Research & Discovery
Production & Clinical
Plus the custom pipelines and research methods each project demands. We came to consulting from the Broad Institute, ultra-accurate sequencing startups, clinical diagnostics labs, academic genomics groups, and sequencing cores — the same environments our clients work in.
Meet the team
From the people we’ve worked with.
“They can act like a fractional bioinformatician for small companies or like a full infrastructure partner for larger teams. Their work is robust and reliable – I never worry about code quality or bugs. They’re also thought partners who provide unexpected insights.”
Dillon FloodHead of Platform, Elsie Biotech (part of GSK)
“By far, the best bioinformatics firm we’ve worked with — exceptional service for seven years running.”
Evan Mauceli, PhDCIO, Directed Genomics (part of NEB)
“Fulcrum has been an essential partner in shaping our clinical-grade workflows and processes.”
Kyle Hernandez, PhDSr. Director, Translational Informatics, Belay Diagnostics
“From day one, Fulcrum Genomics operated like an extension of our team — iterating quickly with us as our protocols evolved and translating cycle-resolved error signatures into clear, actionable insights.”
Yu Zheng, PhDFounder & Co-CEO, Canal Biosciences
“Fulcrum has been a game changer for us. We now have pipelines that outperform anything else available and produce data of such high quality that we’ve expanded our vision for the entire project.”
Elinor KarlssonCo-founder & Chief Scientist, Darwin’s Ark
WHY FULCRUM
Scientific partners with a track record.
We wrote the book
Our founders authored Picard and htsjdk at the Broad Institute, helped define the SAM/BAM and VCF specs, and maintain fgbio; the team holds 500+ publications with 200,000+ citations. If you’ve run a sequencing pipeline, you’ve probably run our code.
Senior team, start to finish
Fourteen PhD-level scientists and engineers, with no junior bench. The people who scope your project are the people who write the code.
Built for regulated work
We’ve helped clients carry bioinformatics pipelines through CLIA/CAP validation, regulatory submission, and clinical launch, more than once. We build to that standard from the start.
Scientists at TwinStrand Bio, Myriad Genetics, Twist Bioscience, and Belay Diagnostics trust us with their most complex data challenges.
RESULTS
Every success story comes with references you can check.
CAP/CLIA clinical launch in ~1 year
Belay Diagnostics needed a CAP/CLIA-grade clinical pipeline for their Summit™ liquid biopsy. We took it from prototype to patients.
~4x lower early-read errors
Canal Biosciences asked us to independently validate their TrueLink™ library prep chemistry ahead of launch.
99.5% genotype accuracy at 0.2x depth
We built the largest feline imputation reference panel for Darwin’s Ark, making population-scale low-pass sequencing viable.
What’s public here is a fraction of our work; the rest stays under strict confidentiality.
Get in touch to see how we can help you.
The code, the IP, and the results are yours, fully documented so your own team can run and maintain them without us.
Every engagement under NDA, delivered in-house by our own US- and Canada-based team. Never offshored, outsourced, or subcontracted.
Founder-owned and independent for 11+ years, with no investors setting the clock. We still maintain the tools we build, like fgbio.