Bioinformatics experts who listen.

Whether you are standing up a first bioinformatics capability or extending an established team, we work at whatever scale you need, from a single analysis to an embedded department.

Every engagement starts with your question.

Our expertise How we work FAQs

Expertise

Our expertise.

We take on genomic analysis that needs both deep methods knowledge and production‑grade engineering.

UMI-based analysis for high-accuracy sequencing
Genome editing and integration-site analysis
Single-cell omics with production-scale processing
High-throughput screening with DNA encoding and NGS readouts
Long-read sequencing validation for structural variants and payload confirmation
Custom pipeline development built specifically for biology

See examples

Engagement models

How we work with you.

Two ways to engage, shaped around where your team is today.

For early-stage companies.

Your Situation: You need bioinformatics capabilities now. Hiring in-house can take many months and significant budget you may not have. Your team is racing towards milestones, and computational analysis has become the bottleneck.
Our Approach: We function as your fractional bioinformatics department, giving you immediate access to 14 specialists across UMI-based analysis, genome editing, single-cell omics, and production-grade pipeline engineering.
What This Looks Like: Flexible capacity that scales up or down with your needs. Direct integration and regular syncs with your wet-lab scientists. No long-term contracts or commitments, just the expertise you need, exactly when you need it.

For established teams.

Your Situation: Your internal bioinformatics team is excellent but overwhelmed. You have budget but face headcount restrictions. New projects require specialized expertise outside your team's current focus areas.
Our Approach: We provide flexible capacity that integrates with your existing workflows. Think of us as specialized reinforcements who tackle specific technical challenges while your team focuses on core priorities.
What This Looks Like: Defined deliverables with clear timelines. Embedded with your bench and computational teams, from experimental design through interpretation. Production-grade documentation and validation.

Work with us

Why teams choose us.

What sets us apart, and how an engagement runs from first call to results.

What makes us different

Production-grade engineering

We build maintainable, validated code that becomes a lasting part of your team’s infrastructure.

Deep biological understanding

We work fluently in both wet-lab science and computation, so nothing gets lost between the two.

Collaborative scientific contribution

We co-author papers, present at conferences, and develop the novel methods the field goes on to use.

Our process

Initial consultation

We discuss your challenges, timeline, and goals. It’s a conversation between scientists, not a pitch.

Scoping & approach

We outline the approach, timeline, and team, so you get a clear picture of exactly what to expect from us.

Rapid start

Once aligned, we deliver results in weeks, with direct integration into your team from the very first day.

Testimonials

What our clients say.

Long-term partnerships with teams across diagnostics, therapeutics, sequencing, forensics, and clinical genomics.

Fulcrum has an insane amount of breadth and depth in their knowledge and capabilities. We have used them to both re-architect our pipelines for good modularity and reusability and develop and validate algorithms to detect complex structural variants and improve our core germline calling accuracy. Best part is they work collaboratively and seamlessly with our internal science and engineering teams and were able to adapt to our cloud infrastructure.

Kevin Haas, PhD

CTO

Myriad Genetics

Fulcrum Genomics has supported our research and product development since the inception of our company. We have been able to accelerate our product development faster than we could have on our own. Fulcrum is capable of being a full bioinformatics team or a support to your existing team. The team at Fulcrum is easy to work with and always productive. Start with a concept, describe the desired outcome and they can build the tools to make you successful.

Keith Brown

CEO

Jumpcode Genomics

Fulcrum Genomics has provided us with exceptional bioinformatics service for over seven years. They work closely with us to understand the goals and pitfalls of each project and always have useful insights to apply towards a solution. Once a plan of action has been agreed upon, they are incredibly quick to implementation, whether it be an R&D toolset or a production informatics pipeline. By far, the best bioinformatics firm that we have worked with.

Evan Mauceli, PhD

CIO

Directed Genomics

Working with Fulcrum Genomics has been an extremely positive and beneficial experience for our company. Their enthusiasm is contagious – we worked as a team, coordinating efforts and meeting aggressive timelines. Their grasp of complex problems with their creative solutions have helped Verogen launch game-changing solutions for the forensic genomics community.

Kathryn Stephens, PhD

VP R&D

Verogen

They can act like a fractional bioinformatician for small companies or like a full infrastructure partner for larger teams. Their work is robust and reliable — I never worry about code quality or bugs. They’re also thought partners who provide unexpected insights.

Dillon Flood

Head of Platform

Elsie Biotech (part of GSK)

From day one, Fulcrum Genomics operated like an extension of our team — iterating quickly with us as our protocols evolved and translating cycle-resolved error signatures into clear, actionable insights.

Yu Zheng, PhD

Founder & Co-CEO

Canal Biosciences

Fulcrum has been an essential partner in shaping our clinical-grade workflows and processes. This partnership has empowered our ability to deliver patients reliable, high-quality results with confidence.

Kyle Hernandez, PhD

Sr. Director of Translational Informatics

Belay Diagnostics

Fulcrum has been a game changer for us. We now have pipelines that outperform anything else available and produce data of such high quality that we’ve expanded our vision for the entire project.

Elinor Karlsson

Co-Founder & Chief Scientist

Darwin’s Ark

The team at Fulcrum Genomics always does first-class work during all phases of engagement. Fulcrum’s expert team has mastered the art of efficient engagement, and is a trusted and valued partner.

Bryan Johnson

SVP Data Science & Engineering

Strata Oncology

FAQs

Frequently asked questions.

How quickly can you get started?

We typically begin delivering results within 1-2 weeks of our initial conversation. There are no lengthy procurement delays or onboarding periods.

Do you work on project or retainer basis?

Both. We offer two engagement models: well-scoped projects with defined deliverables and timelines, and monthly reserved capacity with guaranteed availability. We are happy to work with you in whatever capacity makes sense for your team and organization.

Can we talk to your other clients?

Absolutely. 95% of our business comes from referrals, and our clients are happy to share their experiences. We can connect you with companies similar to yours who have solved comparable challenges.

Do you integrate with existing teams?

Yes. We work directly with your wet-lab and computational teams through Slack, email, or regular meetings. Our relationship can evolve from being your bioinformatics department, to helping you build your own team, to providing long-term expertise and flexible capacity.

What makes you different from other bioinformatics consulting firms or CROs?

Production-grade engineering: our code is robust and maintainable, built to become part of your infrastructure. Deep biological understanding: we bridge wet-lab science and computational analysis, often contributing to experimental design improvements. Scientific contribution: we publish, present at conferences, and develop novel methods.

Do you sign NDAs and work with proprietary data?

Yes. We routinely work under NDAs and handle confidential therapeutic programs, proprietary assays, and unpublished data. Data security and confidentiality are fundamental to how we operate.

What specific bioinformatics expertise do you have?

We work across genomics analysis, including UMI-based analysis for high-accuracy sequencing, genome editing and integration-site analysis (including custom tools like CALITAS), single-cell genomics and transcriptomics with production-scale processing, and long-read sequencing for structural variants.

How do we get started?

Schedule a consultation. We'll discuss your scientific challenges, timeline, and goals, scientist to scientist. Then we'll provide a Statement of Work with our recommended approach, deliverables, timelines, and effort estimates.